What are the "safest" antidepressants for CM

Discussions of issues related to living with cavernous angiomas

What are the "safest" antidepressants for CM

Postby medevac42 » Fri Aug 11, 2017 9:31 pm

I have had both MDD and OCD as a result of my hemorrhage, so my doctor is wanting to put me on an antidepressant to help with these symptoms. I have been doing some research to find those that are least likely to increase the risk of bleeding, but I wanted to ask if anyone has already delved into this issue or might have some helpful information?

The most conclusive information that I have found is the following: "When used as a monotherapy (i.e. not in conjunction with a blood thinner like warfarin), the tricyclic antidepressants (TCA), particularly nortriptyline and amitriptyline, do not appear to increase the risk of bleeding."
source: https://www.uspharmacist.com/article/tr ... on-therapy

Thanks for your input!
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Re: What are the "safest" antidepressants for CM

Postby PattiG » Sat Aug 12, 2017 4:36 pm

Hi and welcome,

To my knowledge, the tricyclic antidepressants you listed are considered 'safe' for us.
Years ago I tried amitriptyline as off-label pain relief, but unfortunately as a side effect it caused my heart to race. :(

Best wishes,
Multiple CMs throughout my brain. I have had 4 bleeds requiring surgery between 1987 and 2010. Locations of craniotomies have been: L. parietal, R. parietal, L. temporal and R. thalamus.
A Central Pain Syndrome Survivor's Perspective http://strokeconnection.strokeassociati ... rspective/
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Joined: Mon Sep 27, 2010 12:38 am
Location: Oregon

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