Is this real or a hoax??

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Is this real or a hoax??

Postby vandy » Thu Dec 06, 2012 4:19 pm

Has Anyone heard anything found in the posting online by the University of California, San Diego
Technology Transfer Office?

The article reads:

Novel Non-Invasive Therapeutic Target for Cerebral Cavernous Malformations
Tech ID: 22924 / UC Case 2013-075-0


Patients with Cerebral cavernous malformations (CCM) are collections of small blood vessels in the brain that are enlarged and irregular in shape, rendering them more predisposed for leakage that often lead to seizures, paralysis, hearing or vision impairment, or hemorrhage. CCM affects approximately 35 million people worldwide. While mutations in the CCM1, CCM2 and CCM3 gene have been found to be associated with CCM, their precise functions are not fully delineated. CCM is currently treated with surgery; there is no existing drug or genetic therapy.

Technology Description

CCM1, CCM2 and CCM3 proteins are known to jointly regulate vasculogenesis, cardiogenesis and endothelial proliferation. UCSD researchers have identified a protein that is downstream of CCM1, which links CCM1 to a well-known signaling pathway. Since several compounds have been found to regulate this signaling pathway, UCSD researchers have found that these compounds alleviate the symptoms of CCM. Therefore proteins in the aforementioned signaling pathway can be potential therapeutic targets for CCM using these known compounds.


An inhibitor and method to interrupt signaling that contributes to vascular disease and CCM pathology is described which have potential as diagnostic and therapeutic products for CCM disease.

State Of Development

Using known inhibitors of this protein, UCSD researchers have shown that cellular dysfunctions related to CCM can be prevented in human or mouse CCM lesion endothelial cells.

Related Materials

Cavalcanti DD, Kalani MY, Martirosyan NL, Eales J, Spetzler RF, Preul MC. Cerebral cavernous malformations: from genes to proteins to disease. J Neurosurg. 2012 Jan;116 (1):122-32. Epub 2011 Sep 30. - 09/30/2011

Patent Status

Patent Pending

Other Information

Categorized As
Disease: Central Nervous System
Related cases

Cerebral cavernous malformation, brain injury, seizure, paralysis, vision impairment, hearing impairment, hemorrhage

University of California, San Diego Technology Transfer Office / / tel: View Phone Number. Please reference Tech ID #22924.

Request Additional Information

This article doesn't seem real, and I have never heard of anything about this anywhere else, yet it is from a University?

Henk :ugeek:
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Re: Is this real or a hoax??

Postby josh » Thu Dec 06, 2012 6:39 pm

Holy smokes. No clue here. Fingers X'd its the real deal. Thanks for post!
Diagnosed at age 35 after brainstem hemorrhage in December 2010."1.0 x 0.4 x 0.9 cm focal lesion in the anterior aspect of the medulla most consistent with cavernous angioma." MRI in March 2012 shows growth and symptoms worsening (sigh). MRI in Sep 2012 maybe shrinking! New bleed in 2014,CM bigger,recovering OK *meh*
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Re: Is this real or a hoax??

Postby vandy » Thu Dec 06, 2012 6:41 pm

Connie replied to this on the Facebook page:

Henk - I'm not sure of the specifics, but UCSD is the original institution that identified fasudil as a potential treatment. They can't patent the drug, but there is something about their discovery that they are trying to patent.

Hope that helps clarify things for you.

Henk :ugeek:
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