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Doxycycline for potential(?) vascular stabilization

PostPosted: Wed Jan 14, 2015 12:28 am
by josh
Hi All!

(typical disclaimer I am not a doctor, talk to your neuro/doctor before trying anything!)

In the quest for vascular stabilization, doxycycline comes up as a focus of research but far from proven for stabilizing cavernous malformation. But it seems interesting anyway and certainly some basic research in this direction. My apologies if this drug has been discussed before for potential treatment.

Below are some research links (the research on doxycycline seems endless btw) ...

Josh

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Suppression of MMP-9 by doxycycline in brain arteriovenous malformations.
http://www.ncbi.nlm.nih.gov/pubmed/15667660 - 2005

Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance.
http://www.ncbi.nlm.nih.gov/pubmed/18212521 - 2008

Expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) in cerebral cavernous malformations:
immunohistochemical analysis of MMP-2, -9 and TIMP-2.
http://www.ncbi.nlm.nih.gov/pubmed/17043747 - 2007

Expressions of angiogenesis associated matrix metalloproteinases and extracellular matrix proteins in cerebral vascular malformations.
http://www.ncbi.nlm.nih.gov/pubmed/20036554 - 2010
-- "MMP-2 and MMP-9 were more strongly expressed in the vascular walls of CCMs compared to cAVMs for all comparable layers: endothelium, subendothelium and the perivascular space."

The role of doxycycline as a matrix metalloproteinase inhibitor for the treatment of chronic wounds.
http://www.ncbi.nlm.nih.gov/pubmed/20031955 - 2010

Doxycycline inhibition of abdominal aortic aneurysm growth: a systematic review of the literature.
http://www.ncbi.nlm.nih.gov/pubmed/21595625 - 2011
-- "However, the human studies, comprising 6 controlled trials and 2 cohort studies, provide conflicting evidence."

Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
http://www.jvascsurg.org/article/S0741- ... 7/abstract - 2009
http://www.jvascsurg.org/article/S0741- ... 1663-7/pdf
-- "Independent of its dose, short-term preoperative doxycycline therapy improves the proteolytic balance in AAA, presumably through an effect on aortic wall neutrophil content. "

Pulmonary capillary hemangiomatosis with atypical endotheliomatosis: successful antiangiogenic therapy with doxycycline.
http://www.ncbi.nlm.nih.gov/pubmed/14605083 - 2003

Search on PubMed for doxycycline
http://www.ncbi.nlm.nih.gov/pubmed/?term=doxycycline+...